Department of
Molecular Biology
and Genetics

Bilkent University
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Özgür ŞAHİN, Ph.D.

Assistant Professor

Mailing
Address
: Bilkent University
Faculty of Science, B Building
Department of
    Molecular Biology and Genetics
06800 Ankara, TURKEY
Office : SB 247
Phone : +90 312 290 2402
Fax : +90 312 266 5097
Email : osahinfen.bilkent.edu.tr
sahinozgurgmail.com

Biosketch

09/2013- Assistant Professor
Bilkent University,
Department of
    Molecular Biology and Genetics,
Ankara, TURKEY
01/2012-
08/2013
Instructor (research faculty)
UT MD Anderson Cancer Center (MDACC),
Department of Molecular and
    Cellular Oncology,
Houston, TX, USA
09/2008-
12/2011
Research group leader
German Cancer Research Center (DKFZ),
Division of Molecular Genome Analysis,
RTK Signaling Group,
Heidelberg, GERMANY
06/2005-
05/2008
Ph.D. (summa cum laude)
Division of Molecular Genome Analysis,
German Cancer Research Center (DKFZ)
    and University of Heidelberg, GERMANY
10/2003-
04/2005
M.Sc. (honor)
International Molecular and
    Cellular Biology Program,
University of Heidelberg and
    German Cancer Research Center
    (DKFZ),
Heidelberg, GERMANY
09/1999-
06/2003
B.Sc. (high honor)
Molecular Biology and Genetics,
Middle East Technical University,
Ankara, TURKEY
GPA: 3.75:4.00       Rank:3/21
06/2002-
08/2002
Research Internship
Institute for Biomedical Engineering,
Swiss Federal Institute of Techology
    (EPFL),
Lausanne, SWITZERLAND

Research Interest and Current Projects

Staining of actin filaments with phalloidin Immunohistochemistry staining of a protein in mouse tumors
Research title: Systems biology of drug resistance and metastasis

Research summary: The major research themes in my lab are systems-level analysis of therapy resistance and metastasis mainly in breast cancer. Importantly, how epithelial-mesenchymal transition (EMT), which is an important initiator step in metastasis, contributes to drug resistance and how we can use this knowledge to better target cancer cells is another focus in my lab. Two most aggressive subtypes of breast cancer, HER2-overexpressing and triple negative breast cancers (TNBCs) as well as ER+ breast cancer are the major disease-foci. In addition to breast cancer, we work on the molecular pathogenesis of gastrointestinal stromal tumors (GISTs).

In this line, we develop:
  1. Transgenic and syngeneic transplantation mouse models of acquired drug resistance;
  2. Primary/established cell line models of acquired drug resistance to combinatorial therapies in 3-D culture;
  3. Different experimental and spontaneous metastasis models in mice.

Combining these models with high-throughput transcriptomics/proteomics approaches, bioinformatics/modeling tools and clinical sample analysis, my research group is aiming at identifying novel targets overcoming resistance to state-of-art clinically-applied or -tested drugs and preventing metastatic spread of breast cancer. At molecular level, two major foci are proteins and non-coding RNAs, especially microRNAs in my lab.

Research keywords: breast cancer / systems biomedicine / therapy resistance / metastasis / microRNAs / GISTs

Lab Members

Lab Website


Department of Molecular Biology and Genetics
Faculty of Science, B Building
Bilkent University
Ankara, Turkey (06800)


Phone: +90 312 290 22 40
Fax: +90 312 266 50 97
E-mail: yildizfen.bilkent.edu.tr