Professional Snapshot

Scientific Focus

Publications

* Vural B, Demirkan A, Ugurel E, Kalaylioglu-Wheeler Z, Esen BA, Gure AO, Gül A, Ozbek U., “Seroreactivity against PTEN-induced putative kinase 1 (PINK1) in Turkish patients with Behçet’s disease,” Clin Exp Rheumatol. 2009 Mar-Apr;27(2 Suppl 53):S67-72. PubMed

* Sabater L, Titulaer M, Saiz A, Verschuuren J, Güre AO, Graus F., “SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome,” Neurology. 2008 Mar 18;70(12):924-8. Epub 2007 Nov 21. PubMed

* Jäger D, Filonenko V, Gout I, Frosina D, Eastlake-Wade S, Castelli S, Varga Z, Moch H, Chen YT, Busam KJ, Seil I, Old LJ, Nissan A, Frei C, Gure AO, Knuth A, Jungbluth AA., “NY-BR-1 is a differentiation antigen of the mammary gland,” Appl Immunohistochem Mol Morphol. 2007 Mar;15(1):77-83. PubMed

* Spisek R, Kukreja A, Chen LC, Matthews P, Mazumder A, Vesole D, Jagannath S, Zebroski HA, Simpson AJ, Ritter G, Durie B, Crowley J, Shaughnessy JD Jr, Scanlan MJ, Gure AO, Barlogie B, Dhodapkar MV., “Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy,” J Exp Med. 2007 Apr 16;204(4):831-40. Epub 2007 Mar 26. PubMed

* Gnjatic S, Nishikawa H, Jungbluth AA, Güre AO, Ritter G, Jäger E, Knuth A, Chen YT, Old LJ., “NY-ESO-1: review of an immunogenic tumor antigen,” Adv Cancer Res. 2006;95:1-30. PubMed

* Zhuang R, Zhu Y, Fang L, Liu XS, Tian Y, Chen LH, Ouyang WM, Xu XG, Jian JL, Güre AO, Fortunato S, Ritter G, Old LJ, Simpson AJ, Chen YT, Jin B, Jungbluth AA., “Generation of monoclonal antibodies to cancer/testis (CT) antigen CT10/MAGE-C2,” Cancer Immun. 2006 Apr 5;6:7. PubMed

* Gure AO, Chua R, Williamson B, Gonen M, Ferrera CA, Gnjatic S, Ritter G, Simpson AJ, Chen YT, Old LJ, Altorki NK., “Cancer-testis genes are coordinately expressed and are markers of poor outcome in non-small cell lung cancer,” Clin Cancer Res. 2005 Nov 15;11(22):8055-62. PubMed

* Chen YT, Venditti CA, Theiler G, Stevenson BJ, Iseli C, Gure AO, Jongeneel CV, Old LJ, Simpson AJ., “Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein,” Cancer Immun. 2005 Jul 7;5:9. PubMed

* Chen YT, Scanlan MJ, Venditti CA, Chua R, Theiler G, Stevenson BJ, Iseli C, Gure AO, Vasicek T, Strausberg RL, Jongeneel CV, Old LJ, Simpson AJ., “Identification of cancer/testis-antigen genes by massively parallel signature sequencing,” Proc Natl Acad Sci U S A. 2005 May 31;102(22):7940-5. Epub 2005 May 19. PubMed

* Vural B, Chen LC, Saip P, Chen YT, Ustuner Z, Gonen M, Simpson AJ, Old LJ, Ozbek U, Gure AO. Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters. Cancer. 2005 Jun 15;103(12):2575-83. PubMed

* Chen YT, Gure AO, Scanlan MJ., “Serological analysis of expression cDNA libraries (SEREX): an immunoscreening technique for identifying immunogenic tumor antigens.” Methods Mol Med. 2005;103:207-16. PubMed

* Chen YT, Alpen B, Ono T, Gure AO, Scanlan MA, Biggs WH 3rd, Arden K, Nakayama E, Old LJ. “Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression.” Genomics. 2003 Dec;82(6):628-36.

* Ayyoub M, Brehm M, Metthez G, Talbot S, Dutoit V, Taub RN, Keohan ML, Gure AO, Chen YT, Williamson B, Jungbluth AA, Old LJ, Hesdorffer CS, Valmori D., “SSX antigens as tumor vaccine targets in human sarcoma.” Cancer Immun. 2003 Oct 9;3:13. PubMed

* Scanlan MJ, Welt S, Gordon CM, Chen YT, Gure AO, Stockert E, Jungbluth AA, Ritter G, Jäger D, Jäger E, Knuth A, Old LJ., “Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets.” Cancer Res. 2002 Jul 15;62(14):4041-7. PubMed

* Gure AO, Wei IJ, Old LJ, Chen YT. The SSX gene family: characterization of 9 complete genes. Int J Cancer. 2002 Oct 10;101(5):448-53. PubMed

* Scanlan MJ, Gure AO, Jungbluth AA, Old LJ, Chen YT., “Cancer/testis antigens: an expanding family of targets for cancer immunotherapy.” Immunol Rev. 2002 Oct;188:22-32. PubMed

* Alpen B, Güre AO, Scanlan MJ, Old LJ, Chen YT. “A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved.” Gene. 2002 Sep 4;297(1-2):141-9. PubMed

* Jäger D, Stockert E, Jäger E, Güre AO, Scanlan MJ, Knuth A, Old LJ, Chen YT., “Serological cloning of a melanocyte rab guanosine 5′-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library.” Cancer Res. 2000 Jul 1;60(13):3584-91. PubMed

* Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O’Hare MJ, Old LJ., “Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.” Cancer Immun. 2001 Mar 30;1:4. PubMed

* Jäger D, Stockert E, Güre AO, Scanlan MJ, Karbach J, Jäger E, Knuth A, Old LJ, Chen YT., “Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library.” Cancer Res. 2001 Mar 1;61(5):2055-61. PubMed

* Güre AO, Stockert E, Scanlan MJ, Keresztes RS, Jäger D, Altorki NK, Old LJ, Chen YT., “Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer.” Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4198-203. PubMed

* Scanlan MJ, Altorki NK, Gure AO, Williamson B, Jungbluth A, Chen YT, Old LJ., “Expression of cancer-testis antigens in lung cancer: definition of bromodomain testis-specific gene (BRDT) as a new CT gene, CT9.” Cancer Lett. 2000 Mar 31;150(2):155-64. PubMed

* Güre AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT., “CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis.” Int J Cancer. 2000 Mar 1;85(5):726-32. PubMed

* Jäger D, Stockert E, Scanlan MJ, Güre AO, Jäger E, Knuth A, Old LJ, Chen YT., “Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene.” Cancer Res. 1999 Dec 15;59(24):6197-204. PubMed

* Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ., “Antigens recognized by autologous antibody in patients with renal-cell carcinoma.” Int J Cancer. 1999 Nov 12;83(4):456-64. PubMed

* Scanlan MJ, Williamson B, Jungbluth A, Stockert E, Arden KC, Viars CS, Gure AO, Gordan JD, Chen YT, Old LJ., “Isoforms of the human PDZ-73 protein exhibit differential tissue expression.” Biochim Biophys Acta. 1999 Apr 14;1445(1):39-52. PubMed

* Türeci O, Chen YT, Sahin U, Güre AO, Zwick C, Villena C, Tsang S, Seitz G, Old LJ, Pfreundschuh M., “Expression of SSX genes in human tumors.” Int J Cancer. 1998 Jul 3;77(1):19-23.

* Chen YT, Güre AO, Tsang S, Stockert E, Jäger E, Knuth A, Old LJ., “Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library.” Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6919-23. PubMed

* Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ., “Characterization of human colon cancer antigens recognized by autologous antibodies.” Int J Cancer. 1998 May 29;76(5):652-8. PubMed

* Güre AO, Altorki NK, Stockert E, Scanlan MJ, Old LJ, Chen YT., “Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3.” Cancer Res. 1998 Mar 1;58(5):1034-41. PubMed

* Gure AO, Türeci O, Sahin U, Tsang S, Scanlan MJ, Jäger E, Knuth A, Pfreundschuh M, Old LJ, Chen YT., “SSX: a multigene family with several members transcribed in normal testis and human cancer.” Int J Cancer. 1997 Sep 17;72(6):965-71. PubMed

* Chen YT, Scanlan MJ, Sahin U, Türeci O, Gure AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ., “A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening.” Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1914-8. PubMed