Upcoming Events

No future events planned for now.

Türkçe

Kamil Can Akçalı, M.D., Ph.D.

Can AkcaliAssistant Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 243

Telephone

+90-312-290 24 18

Fax

+90-312-266 50 97

e-mail

akcali[at]fen[dot]bilkent[dot]edu[dot]tr

Detailed Information »

^ PAGE TOP

Rengul Cetin-Atalay, M.D., Ph.D.

Associate Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 310

Telephone

+ 90-312-290 2503

Fax

+90-312-266 50 97

e-mail

rengul[at]bilkent[dot]edu[dot]tr

URL

http://www.bilkent.edu.tr/~rengul

Detailed Information »

^ PAGE TOP

Ebru Erbay, M.D., Ph.D.

Assistant Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 242

Telephone

+90-312-290 25 05

Fax

+90-312-266 50 97

e-mail

eerbay[at]bilkent[dot]edu[dot]tr

Lab Web Site

http://www.lablife.org/labs/3752

Professional Snapshot

Academic Degrees and Employment

Education

Postdoctoral training: Harvard School of Public Health Ph.D. : University of Illinois, Urbana-Champaign M.D. : Akara University

Employment

Assistant Professor: Bilkent University

Research Associate: Harvard School of Public Health Postdoctoral Fellow : Harvard School of Public Health

Lab Members

Busra Yagabasan, Erdem Terzi, Inci Simsek, Ozlem Tufanli, Seda Koyuncu, Cansu Tekin, Cagla Comert, Elif Kayali, Kubra Eren, Nil Aygun, Selin Kenet, Elcin Kinikli

Scientific Focus

Research Interests

The overall resarch focus:
Lipotoxic endoplasmic reticulum stress in cardiometabolic syndrome: My laboratory’s research focus is at the intersection of nutrient-sensitive, inflammatory and stress pathways in the context of chronic inflammatory and metabolic diseases. Metabolic overload leads to endoplasmic reticulum (ER) stress and activates the unfolded protein response (UPR). The UPR is essentially an adaptive signaling emanating from the ER to cope with cellular stress. Our major goal is to probe the molecular differences between the detrimental consequences of metabolic ER stress and the adaptive UPR that could be therapeutically exploited in chronic metabolic and inflammatory diseases. We are mainly interested in the molecular and cellular mechanisms by which the ER receives and regulates the lipid status of the cells in the context of metabolic diseases. We developed a chemical-genetic approach to specifically modulate several proximal kinases in the UPR. This method allows mono-specific activation or inhibition of only the modified kinase in cells and tissues and will enable targeting of individual arms of the UPR governed by these kinases. Furthermore, this will be coupled to substrate discovery and creation of transgenic mouse models where the activity of these essential kinases can be regulated at specific points during chronic metabolic and inflammatory disease process. This work involves a multidisciplinary approach including chemical-genetics, cell biology, proteomics, metabolomics, transgenic mice, and in vivo disease modeling.

Supported by: European Commission, European Molecular Biology Organization, TUBITAK (Turkey) and BMBF (Germany)
Project 1: The Impact of Bioactive Lipokines on Atherosclerosis
Supported by European Commission
Collaborators: Gökhan S. Hotamışlıgıl (Harvard School of Public Health)
Mac Rae Linton and Vladamir Babaev (Vanderbilt University)
Project 2: Novel Molecular and Therapeutic Targets in Cardiometabolic Syndrome: Liptoxic Endoplasmic Stress
Supported by TUBITAK (Turkey) and BMBF (Germany)
Collaborator: Christian Weber (Ludwig Maximillians Universitat)
Project 3: Novel Mechanisms in Lipotoxic Endoplasmic Stress
Supported by European Molecular Biology Organization
Project 4: Delineation of lipotoxic endoplasmic stress pathway
Collaborator: Peter Walter (University of California San Francisco, HHMI)
Project 5: Consanguinity based dissection of obesity
Collaborators: Jeffrey Friedman (Rockerfeller University), Tayfun Özçelik (Bilkent University), Bülent Yıldız (Hacettepe University), Can Alkan (Bilkent University)
Project 6: Identification of differentially expressed miRNAs and analysis of the genes regulated by them during lipid stess
Supported by TUBITAK (A.A.)
Collaborator: Arzu Atalay (Ankara University Biotechnology)

Publications

Babaev VR, Runner RP, Fan D, Ding L, Zhang Y, Tao H, Erbay E, Görgün CZ, Fazio S, Hotamisligil GS, Linton MF
Arterioscler Thromb Vasc Biol. 2011 Apr 7. ():.

Erbay E, Babaev VR, Mayers JR, Makowski L, Charles KN , Snitow ME, Fazio S, Wiest MM, Watkins SM, Linton MF, Hotamisligil GS
Nat Med. 2009 Dec . 15(12):1383-91.

Hotamisligil GS, Erbay E
Nat Rev Immunol. 2008 Dec . 8(12):923-34.

Erbay E, Cao H, Hotamisligil GS
Curr Atheroscler Rep. 2007 Sep . 9(3):222-9.

Tuncman G , Erbay E, Hom X, De Vivo I, Campos H, Rimm EB, Hotamisligil GS
Proc Natl Acad Sci U S A. 2006 May 2. 103(18):6970-5.

Park IH, Erbay E, Nuzzi P, Chen J
Exp Cell Res. 2005 Sep 10. 309(1):211-9.

Erbay E, Park IH, Nuzzi PD, Schoenherr CJ, Chen J
J Cell Biol. 2003 Dec 8. 163(5):931-6.

^ PAGE TOP

Ali Osmay Güre, M.D., Ph.D.

Ali GureAssistant Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 248

Telephone

+90-312-290 25 07

Fax

+90-312-266 50 97

e-mail

agure[at]bilkent[dot]edu[dot]tr

Detailed Information »

^ PAGE TOP

İhsan Gürsel, Ph.D.

Ihsan GürselAssociate Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 244

Telephone

+90-312-290 24 08

Fax

+90-312-266 50 97

e-mail 1

ihsangursel[at]bilkent[dot]edu[dot]tr

e-mail 2

igursel[at]fen[dot]bilkent[dot]edu[dot]tr

Detailed Information »

^ PAGE TOP

Özlen Konu, Ph.D.

Ozlen Konu

Assistant Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 245

Telephone

+90-312-290 21 23

Fax

+90-312-266 50 97

e-mail

konu[at]fen[dot]bilkent[dot]edu[dot]tr

Detailed Information »

^ PAGE TOP

Tayfun Özçelik, M.D.

Professor of Human Genetics

Mailing AddressTayfun_Ozcelik

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 238

Telephone

+90-312-290 21 39

Fax

+90-312-266 50 97

e-mail

tozcelik[at]bilkent[dot]edu[dot]tr

Detailed Information »

^ PAGE TOP

Mehmet Öztürk, Ph.D.

Mehmet Ozturk

Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 306

Telephone

+90-312-266 45 38

+90-312-290 21 54

Fax

+90-312-266 50 97

e-mail

ozturk[at]fen[dot]bilkent[dot]edu[dot]tr

Detailed Information »

^ PAGE TOP

Uygar H. Tazebay, Ph.D.

Uygar Tazebay

Assistant Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 246

Telephone

+90-312-290 24 19

Fax

+90-312-266 50 97

e-mail

tazebay[at]fen[dot]bilkent[dot]edu[dot]tr

Detailed Information »

^ PAGE TOP

Işık Yuluğ, Ph.D.

Isik Yulug_2

Associate Professor

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 241

Telephone

+90-312-290 25 06

Fax

+90-312-266 50 97

e-mail

yulug[at]fen[dot]bilkent[dot]edu[dot]tr

Detailed Information »

^ PAGE TOP

© Bilkent University. Copyright statement.
Institute of Engineering and Science

Announcements Feed Calendar Feed