Gürsel Lab
Publications: PATENTS 1. D.M. Klinman, M. Gursel and İ. Gürsel , Methods of altering an immune response induced by CpG oligodeoxynucleotides, US patent pending, 2005. 2. D. Verthelyi, İ. Gürsel , M. Gursel, R. Zeuner, and D.M. Klinman, Method of treating inflammatory arthropathies with suppressors of CpG oligodeoxynucleotides (PCT patent, publication number: WO2004012669, publication date: 02-23-2004) . 3. D.M. Klinman,M. Gursel, İ. Gürsel ,R. Zeuner, and D. Verthelyi, Suppressors of CpG oligonucleotides and methods of use (PCT patent publication number: WO03027313, publication date 04-07-2003) . 4. D.M. Klinman, İ. Gürsel , K.J. Ishii, K. Kawakami, B.H.Joshi, and R.K. Puri., Use of sterically stabilized cationic liposomes to efficiently deliver CpG oligodeoxynucleotides in vivo (PCT patent, publication number: WO03040308, publication date: 05-15-2003). 5. G. Gregoriadis, S.G. Antimisiaris, and İ. Gürsel ,Liposomes containing particulate materials, (PCT Application: GB/94-02191, PCT Publication Number: WO 95/09610, licensed in 7 different countries). 6. D.M. Klinman and İ. Gürsel , CpG Oligodeoxynucleotides encapsulated in sterically stabilized cationic liposomes as immunotherapeutic agents (US. Patent Pending, 2001, DHHS Reference No. E-215-01/0). 7. D.M. Klinman, İ. Gürsel ,and M. Gursel, Identification of DNA sequence motifs that suppress the immune response to CpG DNA, (US. Patent Pending, 2001, DHHS Reference No. E-218-01/0). Research Articles: (selected from over 50 publications) 1.  H. Shirota, İ. Gürsel, M. Gursel, D.M. Klinman, Suppressive oligodeoxynucleotides protect mice from lethal endotoxic shock, J. Immunol. 174(8):4579-4583, 2005 2. H. Xie, İ. Gürsel, B. Ivins, D.O`Hagan, J. Ulmer, D.M. Klinman, CpG oligodeoxynucleotides adsorbed onto PLG microparticles improve the immunogenicity and efficacy of anthrax vaccine, Infect. Immun. 73(2):828-833, 2005 3. D. M. Klinman, D. Currie, İ. Gürsel, D. Verthelyi, Use of CpG oligodeoxynucleotides as immune adjuvants, Immunol. Rev. 199:201-216, 2004 4. K. J. Ishii, İ. Gürsel, M. Gursel, D. M. Klinman, Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides, Curr. Op. Mol. Ther. 6(2):166-174, 2004 5. F. Takeshita, İ. Gürsel, K. J. Ishii, K. Suzuki, M. Gursel, D.M. Klinman, Signal transduction pathways mediated by the interaction of CpG DNA with toll-like receptor 9, Semin. Immunol. 16, 17-22, 2004 6. K. J. Ishii, K. Kawakami, İ. Gürsel, B. H. Joshi, D. M. Klinman, R. K. Puri. Anti-tumor therapy with bacterial DNA and toxin: complete regression of established tumor induced by liposomal CpG ODN plus IL-13 cytotoxin, Clin. Cancer Res. 9(17) , 6516-6522, 2003 7. D. M. Klinman, R. A. Zeuner, H. Yamada, M. Gursel, D. Currie, İ. Gürsel, Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides, Ann. N.Y. Acad. Sci. 1002, 112-123, 2003 8. İ. Gürsel, M. Gursel, H. Yamada, F. Takeshita, K. J. Ishii, D. M. Klinman, Repetitive elements present in mammalian telomeres suppress CpG DNA induced immune activation, J. Immunol. 171:1393-1400, 2003 (this study was picked as the cover story: http://www.jimmunol.org/content/vol171/issue3/cover.shtml ). 9. A. Yagmurlu, M. Barlas, İ. Gürsel. I. H. Gokcora, Reduction of injury induced peritoneal adhesions by continuous release of streptokinase from a drug delivery system, Eur.Surg.Res. 35(1):46-49, 2003 10. H. Yamada, İ. Gürsel, F. Takeshita, J. Conover, K. J. Ishii, M. Gursel, S. Takeshita, and D. M. Klinman, Effect of Suppressive DNA on CpG induced immune activation, J. Immunol. 169: 5590-5594, 2002. 11. D. M. Klinman, K. J. Ishii, İ. Gürsel, Immunoprotective activity of CpG oligonucleotide, In. Microbial DNA and Host Immunity, ed. Raz E, Humana Press, 255-263, 2002. 12. R. A. Zeuner, K. J. Ishii, M. Lizak, İ. Gürsel, H. Yamada, D. M. Klinman, D. Verthelyi, Prevention of inflammatory arthritis by suppressive oligodeoxynucleotides, Arthritis Rheum. 46(8) 2219-2224, 2002 . 13. D. M. Klinman , F. Takeshita , İ. Gürsel, C. Leifer, K. J. Ishii, D. Verthelyi, M. Gursel , CpG DNA: recognition by and activation of monocytes, Microbes Infection,4(9) 897-901, 2002. 14. K. J. Ishii, F. Takeshita, İ. Gürsel, M. Gursel, J. Conover, A. Nussenzweig, D. M. Klinman, Potential role of PI3 kinases, rather than DNA-PK, in CpG DNA induced immune activation, J. Exp. Med. 196(2):269-74, 2002. 15. M. Gursel, D. Verthelyi, İ. Gürsel, K. J. Ishii, D. M. Klinman, Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide, J. Leuko. Biol, 71(5):813-820, 2002. 16. H. A. Anderson, R. Englert, İ. Gürsel, E. Shacter, Oxidative stress inhibits the phagocytosis of apoptotic cells that have externalized phosphatidylserine, Cell Death Differ. 9(6):616-625, 2002. 17. F. Takeshita, C. Leifer, İ. Gürsel, M. Gursel, K. J. Ishii, D. M. Klinman, Role of Toll-like receptor-9 in CpG DNA induced activation of human cells. J. Immunol.(cutting edge). 167(7):3555-3558, 2001. 18. İ. Gürsel, M. Gursel, K. J. Ishii, D. M. Klinman, Sterically stabilized cationic liposomes improve the uptake and immunostimulatory activity of CpG oligonucleotides, J. Immunol. 167(6):3324-3328, 2001. 19. F. Korkusuz, P. Korkusuz, F. Eksioglu, İ. Gürsel, V. Hasirci, In vivo response to biodegradable antibiotic release systems, J. Biomed. Mater. Res. 55:217-228, 2001. 20. İ. Gürsel, F. Korkusuz, F. Turesin, N. G. Alaeddinoglu, V. Hasirci, In vivo application of biodegradable controlled antibiotic release systems for the treatment of implant-related osteomyelitis, Biomaterials, 22:(1) 73-80, 2001. 21. D. M. Klinman, S. Kampstrup, D. Verthelyi, İ. Gürsel , K. J. Ishii, F. Takeshita, M. Gursel, Activation of the innate immune system by CpG: Therapeutic applications and safety issues, Springer Semin. Immunopharmacol. 2(1-2): 173-183, 2000. 22. D. M. Klinman, K. J. Ishii, M. Gursel, İ. Gürsel , S. Takeshita and F. Takeshita, Immunotherapeutic applications of CpG containing oligodeoxynucleotides, Drug News and Perspectives 13(5),289-296, 2000. 23. F. Türesin, Z. Gümüsyazici, F. N. Kök, İ. Gürsel , N. G. Alaeddinoglu V. Hasirci, Biosynthesis of polyhydroxybutyrate and its co-polymers and their use in controlled drug release, Turkish J. Med. Sci 30:535-541 2000. 24. D. Sendil, İ. Gürsel , V. Hasirci, Preparation of PHBV foams and investigation of their potential for drug release, Tr. J. Med. Sci. 30: 9-14, 2000. 25. F. Eksioglu, İ. Gürsel, F. Korkusuz, V. Hasirci, Novel antibiotic carrying biodegradable implant for the treatment of bone infections, J. Bone Joint Surg. [BR] 81-B: Supp II p.179, 1999. 26. M.F. Yagmurlu, F. Korkusuz, İ. Gürsel, P. Korkusuz, U. Ors, V. Hasirci, Sulbactam-cefoperazone polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic delivery system: In vivo effectivity and biocompatibility in the treatment of implant related experimental osteomyelitis, J. Biomed. Mater. Res.46, 494-503, 1999. 27. S. Bayari, F. Severcan, İ. Gürsel , V. Hasirci, N. G. Alaeddinoglu, The FTIR studies of PHB and PHBV, In. New Biomedical Materials, eds. P. I. Harris and D. Chapman, IOS Press, 58-64, 1998. 28. D. Sendil, İ. Gürsel , D. L. Wise, and V. Hasirci, Antibiotic Release from biodegradable PHBV microparticles, J. Contr. Rel.59,207-217, 1999. 29. İ. Gürsel, C. Balçık, Y. Arica, O. Akkus, N. Akkas, V. Hasirci, Synthesis and mechanical properties of interpenetrating networks of polyhydroxybutyrate-co-hydroxyvalerate and polyhydroxyethyl methacrylate, Biomaterials,19(13):1137-1143, 1998. 30. İ. Gürsel, N. G. Alaeddinoglu, Bacterial polyhydroxyalkanoates: Biosynthesis, screening and characterization, In. Biopharmaceutical and Biomedical Science and Technology, eds. A.A. Hıncal, H. S. Kas, Plenum Press, NY, USA, 81-88, 1998. 31. İ. Gürsel, D. Sendil, D. L. Wise, V. Hasirci, Antibiotic release from biodegradable PHBV microparticles, In. Biopharmaceutical and Biomedical Science and Technology, eds. A.A. Hıncal, H. S. Kas, Plenum Press, NY, USA, 89-96, 1998. 32. V. Hasirci, İ. Gürsel , F. Turesin, G. Yigitel, F. Korkusuz, N. G. Alaeddinoglu, In. Biopharmaceutical and Biomedical Science and Technology, Eds. A.A. Hıncal ve H. S. Kas, Plenum Press, NY, USA, 183-187, 1998 33. İ. Gürsel, Y. Arica, V. Hasirci, Immobilization of glucose oxidase and urease, in hydrogel matrices, Turkish J. Chem. 21(4):387-393, 1997. 34. G. Gregoriadis, İ. Gürsel, M. Gursel, B. Mc. Cormack, Liposomes as immunological adjuvants and vaccine carriers, J. Contr. Rel. 41:49-56, 1996. 35. G. Gregoriadis, İ. Gürsel, and S. G. Antimisiaris, Microbe entrapment in giant liposomes, In: Non-Medical Applications of Liposomes:"From Gene Delivery and Diagnostics to Ecology" , eds. D. L. Lasic and Y. Barenholz, CRC Press, Boca Raton, Vol. IV, 263-269, 1996. 36. İ. Gürsel, C. Balcik, Y. Arica, O. Akkus, V. Hasirci, and N. Akkas, Interpenetrating networks of polyhydroxybutyrate-co-hydroxyvalerate, and polyhydroxyethyl methacrylate : Mechanical properties, Engineering Systems Design and Analysis, 5:107-111, 1996. 37. İ. Gürsel, Use of microbial polyhydroxyalkanoates in the construction of biomedical drug release systems, Ph. D. Thesis (M.E.T.U), February 1995. 38. İ. Gürsel, and V. Hasirci, Microcapsules of PHB and PHBV: morphology and release characteristics, J. Microencapsulation, 12(2):185-193, 1995. 39. İ. Gürsel, P.Jayasekera, S. G. Antimisiaris, and G. Gregoriadis, Giant Liposomes as potential vehicles for live or attenuated microbial vaccines, In: Liposomes in Biomedical Applications, ed. P. Shek, Harwood Academic Publishers, Chur, 35-50, 1995. 40. İ. Gürsel, and V. Hasirci, Matrix entrapment of glucose oxidase by gamma-irradiation, Biomaterials, 13(3):150-155, 1992. [Home] [Lab Members] [Research Interest] [Graduate Study] [Publications] [Photos] [Links] [Contact] .	Publications Home Lab Members Ex-Lab Members Research Interest Graduate Study Publications Photos Links Contact Bilkent Main Campus Faculty of Science Bld. B/ # 244 Department of Molecular Biology and Genetics. 06800 Bilkent Ankara TURKEY Phone: (+90)(312) 290 2408