Department Chairman

Prof. Tayfun Özçelik, M.D.

Mailing Address

Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY

Office

Science B 242

Telephone

+90-312-290 21 39

Fax

+90-312-266 50 97

e-mail

Research Interests

  • Rett syndrome
  • X-chromosome inactivation and genetic diseases
  • Molecular genetics of inherited cancer

Academic Degrees and Employment

Education
  • Prof. - Bilkent University 2004
  • Assoc. Prof. Genetics - Istanbul University 1993
  • Assist. Prof. Genetics - Istanbul University 1992
  • Specialist in Medical Genetics 1990
  • M.D. Istanbul University 1986 (Diploma No: 18497-21965)

Employment

  • 1995-present Professor of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
  • 1998-2000 Deputy Director BilGen, Bilkent University, Ankara, Turkey
  • 1993-1995 Associate Professor and Head of the Dept. of Genetics Institute for Experimental Medicine Istanbul University, Istanbul, Turkey
  • 1992-1993 Assistant Professor, Head of the Dept. of Genetics, and Vice-Director of the Institute for Experimental Medicine Istanbul University, Istanbul, Turkey
  • 8/1990 Specialty in Medical Genetics Dissertation "SYP1 ve SYP2 genlerinin kromozomal lokalizasyonlari" Uta Francke, Stanford University

Publications

  • Sevinc A, Yannoukakos D, Konstantopoulou I, Manguoglu E, Luleci G, Colak T, Akyerli C, Colakoglu G, Tez M, Sayek I, Gerassimos V, Nasioulas G, Papadopoulou E, Florentin L, Kontogianni E, Bozkurt B, Kocabas NA, Karakaya AE, Yulug IG, Ozcelik T. Lack of association between RNASEL Arg462Gln variant and the risk of breast cancer. Anticancer Res. 2004 Jul-Aug;24(4):2547-9.
  • Tez M, Gocmen E, Ozcelik T. HER2 and proliferation of wound-induced breast carcinoma. Lancet. 2003 Nov 1;362(9394):1503.
  • Akgul H, Tez M, Unal AE, Keskek M, Sayek I, Ozcelik T. Echinococcus against cancer: why not? Cancer. 2003 Nov 1;98(9):1999-2000.
  • Akyerli CB, Ozbek U, Aydin-Sayitoglu M, Sirma S, Ozcelik T. Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias. J Cancer Res Clin Oncol. 2003 Oct;129(10):604-5.
  • Manguoglu AE, Luleci G, Ozcelik T, Colak T, Schayek H, Akaydin M, Friedman E. Germline mutations in the BRCA1 and BRCA2 genes in Turkish breast/ovarian cancer patients. Hum Mutat. 2003 Apr;21(4):444-5.
  • Ozcelik T. Uncovering the complex mysteries of mosaicism. Nature. 2002 Jun 6;417(6889):588.
  • Topcu M, Akyerli C, Sayi A, Toruner GA, Kocoglu SR, Cimbis M, Ozcelik T. Somatic mosaicism for a MECP2 mutation associated with classic Rett syndrome in a boy. Eur J Hum Genet. 2002 Jan;10(1):77-81.
  • Sullivan A, Yuille M, Repellin C, Reddy A, Reelfs O, Bell A, Dunne B, Gusterson BA, Osin P, Farrell PJ, Yulug I, Evans A, Ozcelik T, Gasco M, Crook T. Concomitant inactivation of p53 and Chk2 in breast cancer. Oncogene. 2002 Feb 21;21(9):1316-24.
  • Toruner GA, Ucar A, Tez M, Cetinkaya M, Ozen H, Ozcelik T. P53 codon 72 polymorphism in bladder cancer--no evidence of association with increased risk or invasiveness. Urol Res. 2001 Dec;29(6):393-5.
  • Toruner GA, Akyerli C, Ucar A, Aki T, Atsu N, Ozen H, Tez M, Cetinkaya M, Ozcelik T. Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population. Arch Toxicol. 2001 Oct;75(8): 459-64.
  • Ustun C, Arat M, Celebi H, Akan H, Ilhan O, Ozcelik T, Burgess RE, Koc H. Extramedullary relapse following allogeneic stem cell transplantation in acute promyelocytic leukemia: the role of ATRA. Haematologica. 2001 Oct;86(10):E31.
  • Topaloglu R, Akierli C, Bakkaloglu A, Aydintug O, Ozen S, Besbas N, Ozcelik T. Survey of factor V leiden and prothrombin gene mutations in systemic lupus erythematosus. Clin Rheumatol. 2001;20(4):259-61.
  • Beksac M, Ma M, Akyerli C, DerDanielian M, Zhang L, Liu J, Arat M, Konuk N, Koc H, Ozcelik T, Vescio R, Berenson JR. Frequent demonstration of human herpesvirus 8 (HHV-8) in bone marrow biopsy samples from Turkish patients with multiple myeloma (MM) . Leukemia. 2001 Aug;15(8):1268-73.
  • Mazoyer S, ٱ Özçelik T et al. The BRCA1 Exon 13 Duplication Screening Group. “The exon 13 duplication in the BRCA1 gene is a founder mutation present in geographically diverse populations”. Am J Hum Genet 67: 207-212 (2000).
  • Özdag H, Tez M, Sayek I, Müslümanoglu M, Tarcan O, Içli F, Öztürk M,Özçelik T. “Germ-line BRCA1 and BRCA2 gene mutations in Turkish breast cancer patients”. Eur J Cancer 36: 2076-2082 (2000).
  • Ustun C, Arslan O, Beksac M, Koc H, Gurman G, Ozcelik T, Yilmaz B, Ilhan O, Akan H, Ozcan M, Demirer T, Uysan A, Konuk N, Arat M, Dilek I, Celebi H, Coskun HS. “A retrospective comparison of allogeneic peripheral blood stem cell and bone marr ow transplantation results from a single center: a focus on the incidence of graft-vs.- host disease and relapse”. Biol Blood Marrow Transplant (1): 28-35 (1999).
  • Ricciardone MD, Ozcelik T, Cevher B, Ozdag H, Tuncer M, Gurgey A, Uzunalimoglu O, Cetinkaya H, Tanyeli A, Erken E, Ozturk M. “Human MLH1 deficiency predisposes to hematological malignancy and Neurofibromatosis type 1”. Cancer Res 59 : 290-293 (1999).
  • Gul A, Aslantas AB, Tekinay T, Konice M, Ozcelik T. “Procoagulant mutations and venous thrombosis in Behçet’s disease”. Rheumatology 38: 1298-1299 (1999).
  • Vural B, Atlioglu E, Kolusayin Ö, Togan I, Büyükdevrim S, Özçelik T. “Turkish population data on the HLA-Da, LDLR, GYPA, HBGG, D7S8, and GC loci”. Int J Legal Med 111 (1): 43-45 (1998).
  • Hatemi AC, Cine N, Ozcelik T. "Allele and genotype frequencies of the insertion/deletion polymorphism in the human angiotensin converting enzyme in the Turkish population". Turkish J Med 27: 205-208 (1997).
  • Ozbek U, Vural B, Kalayoglu S, Soysal T, Bilgen H, Yavuz S, Anak S, Sargin D, Gedikoglu G, Ferhanoglu B, Akoglu T, Tangun Y, Ozcelik T. "Evaluation of chimerism with DNA polymorphisms in the Turkish population". Turkish J Ped 39: 303-312 (1997).
  • Deymeer F, Serdaroglu P, Poda M, Gulsen-Parman Y, Ozcelik T, Ozdemir C. “Segmental distribution of muscle weakness in SMAIII: implications for deterioration in muscle strength with time”. Neuromuscul Disord 7 (8): 521-528 (1997).
  • Kyriallis K, Christodoulou K, Al-Shehab A, Barba V, Mylonas Y, Mavromatis J, Serdaroglu P, Ozcelik T, Deymeer F, Ozdemir C, Middleton LT. "Familial Infantile Myasthenia in Eastern Mediterranean Countries. Neurology 46: P04.089 (1996).
  • Gül A, Özbek U, Öztürk C, Inanç M, Koniçe M, Özçelik T. "Coagulation factor V mutation and the development of venous thrombosis in Behcet's disease". Brit J Rheum 35: 1178-1180 (1996).
  • Gül A, Özbek U, Öztürk C, Inanç M, Koniçe M, Özçelik T. "Coagulation factor V mutation increases the risk of venous thrombosis in Behcet's disease". Revue du Rheumatisme No 7-8: F10 545 (1996).
  • Anders DA, Milatovich A, Ozcelik T, Wenzlau JM, Brown MS, Goldstein JL, Francke U. "cDNA cloning of the two subunits of human CAAX Farnesyltransferase gene and mapping of FTNA and FTNB loci and related sequences". Genomics 18: 105-112 (1993).
  • Ibraghimov-Beskrovnaya O, Milatovich A, Ozcelik T, Yang B, Koepnick K, Francke U, and Campbell K. "Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization. Hum Molec Genet 2: 1651- 1657 (1993).
  • Davidson JJ, Ozcelik T, Hamacher C, Willems PJ, Francke U, Kilimann MW: cDNA cloning of a liver isoform of the phosphorylase kinase a subunit and mapping of the gene to Xp22.2-p22.1, the region of the human X-linked liver glycogenosis". Proc Natl Ac ad Sci, USA 89: 2096-2100 (1992).
  • Murphy PM, Ozcelik T, Kenney RT, Tiffany HL, McDermott D, and Francke U. "A structural homologue of the N-formyl peptide receptor: Characterization and chromosome mapping of a peptide chemoattractant receptor family". J Biol Chem 267: 11, 7637-7643 (1992).
  • Suter U, Welcher AA, Ozcelik T, Snipes GJ, Kosaras B, Francke U, Billings-Gagliardi S, Sidman RL, and Shooter EM. "Trembler mouse carries a point mutation in a myelin gene". Nature 356: 241-244 (1992).
  • Lindgren V, Bryke CR, Ozcelik T, Yang-Feng TL, and Francke U. "Phenotypic cytogenetic and molecular studies of three patients with constitutional deletions of chromosome 5 in the region of the gene for familial adenomatous polyposis. Am J Hum Genet 50: 988-997 (1992).
  • Ozcelik T, Porteus MH, Rubenstein JLR, and Francke U. "DLX2 (TES1), a homeobox gene for the Distal-less family, assigned to conserved regions on human and mouse chromosome 2". Genomics 13: 1157-1161
  • Berkemeier LR, Ozcelik T, Francke U, and Rosenthal A. "Human chromosome 19 contains the Neurothrophin-5 gene locus and three related genes that may encode novel acidic neurotrophins. Somat Cell and Molec Genet 18: 3, 233-245 (1992).
  • Rupp F, Ozcelik T, Linial M, Peterson U, Francke U, and Scheller R. "Structure and chromosomal localization of the mammalian agrin gene. J of Neurosci 12: 9, 3535-3544 (1992).
  • Ahuja SK, Ozcelik T, Milatovich A, Francke U and Murphy P: Molecular evolution of the human interleukin-8 receptor gene cluster. Nature Genet 2: 31-36 (1992).
  • Ozcelik T, Leff S, Robinson W, Donlon T, Lalande M, Sanjines E, Schinzel A, and Francke U. "Small nuclear ribonucleoprotein N (SNRPN), an expressed gene in the Prader-Willi syndrome critical region. Nature Genet 2: 265-269 (1992).
  • Leff SE, Brannan CI, Reed ML, Ozcelik T, Francke U, Copeland NG, Jenkins NA. "Maternal imprinting of the mouse Snrpn gene and conserved linkage homology with the human Prader-Willi syndrome region. Nature Genet 2: 259-264 (1992).
  • Lindgren V, Bryke CR, Ozcelik T, Yang-Feng TL, Francke U. "Reply to Rivera". Am J Hum Genet 53: 533-534 (1993).
  • Perin MS, Johnston PA, Ozcelik T, Jahn R, Francke U, and Sudhof TC. "Structural and functional conservation of synaptotagmin (p65) in drosophila and humans". J Biol Chem 266: 1, 615-622 (1991).
  • Ozcelik T, Rosenthal A, Francke U. Chromosomal mapping of brain-derived neurotrophic factor and neurotrophin-3 genes in man and mouse". Genomics 10: 569-575 (1991).
  • Ozcelik T, Suedhof TC, Francke, U : Chromosomal assignments of genes for vacuolar (endomembrane) proton pump subunits VPP1/Vpp-1(116 kDa) and VPP3/Vpp-3 (58 kDa) in human and mouse. Cytogenet Cell Genet 58: 2008-2009 (1991).
  • Ozcelik T, Suedhof TC, Francke U : The genes for inositol1,4,5-triphosphate receptors 1 (ITPR1) and 3 (ITPR3) are localized on human chromosomes 3p and 6pter-p21, respectively. Cytogenet Cell Genet 58: 1880 (1991).