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Mailing Address |
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Bilkent University
Faculty of Science, B Building
Department of Molecular Biology and Genetics
06800 Ankara, TURKEY |
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Telephone |
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+90-312-290 24 08 |
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Fax |
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+90-312-266 50 97 |
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e-mail |
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Research
Interests |
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1. Evaluation of immunoprotective, anti-cancer and immunoadjuvant effects of
synthetic oligodeoxynucleotides expressing CpG motifs.
2. Determination of gene expression and transcriptional profiling of immune
cells via high throughput screening using gene chips.
3. Designing controlled release systems for o ligodeoxynucleotide targeting and
delivery.
4 . Investigation of immunomodulatory properties of bacterial and mammalian DNA.
5. Use of novel biodegradable polymers for biomaterials, tissue engineering, and
drug delivery applications. 6. The role of Toll-like receptor (TLR) and
TLR-ligand interactions (alone or in combination) in triggering an innate immune
response.
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Academic Degrees
and Employment |
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Education
- 1998, Docent Degree Higher Education Council ( Ankara, TURKEY)
- 1995, Ph.D. Middle East Technical University (METU), Department of
Biological Sciences, ( Ankara, TURKEY)
- 1989, M.Sc. METU, Department of Biological Sciences, ( Ankara,
TURKEY)
- 1987, B.Sc. METU, Department of Biological Sciences, with Honors (
Ankara, TURKEY)
Employment
- 2005-Present Assistant Professor, Department of Molecular Biology and
Genetics, Bilkent University
- 2002-2005 Staff Scientist-Regulatory Personnel , Food and Drug
Administration, Center for Biologics Evaluation and Research, Division of
Viral Products, ( USA)
- 1998-2002 Visiting Research Fellow, Food and Drug Administration, Center
for Biologics Evaluation and Research, Division of Viral Products, ( USA)
- 1997-1998 Assistant. Professor , METU, Department of Biological Sciences,
( TURKEY)
- 1996-1997 Lecturer , METU, Department of Biological Sciences, ( TURKEY)
- 1993-1994 Research Scientist , University of London, The School of
Pharmacy, Center for Drug Delivery Research ( UK)
- 1987-1995 Teaching and Research Assistant , METU, Department of Biological
Sciences
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Publications |
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- H. Shirota, İ. Gürsel, M. Gursel, D.M. Klinman, Suppressive
oligodeoxy-nucleotides protect mice from lethal endotoxic shock,
J. Immunol. 174(8):4579-4583, 2005
- H. Xie, İ. Gürsel , B. Ivins, D.O`Hagan, J. Ulmer, D.M.
Klinman, CpG oligodeoxynucleotides adsorbed onto PLG
microparticles improve the immunogenicity and efficacy of anthrax
vaccine, Infect. Immun. 73(2):828-833, 2005
- D . M. Klinman, D . Currie, İ. Gürsel , D . Verthelyi, Use of
CpG oligodeoxynucleotides as immune adjuvants, Immunol. Rev.
199:201-216, 2004
- K.J. Ishii,İ. Gürsel, M. Gursel, D. M. Klinman,
Immunotherapeutic utility of stimulatory and suppressive
oligodeoxynucleotides, Curr. Op. Mol. Ther. 6(2):166-174, 2004
- F. Takeshita, İ. Gürsel, K.J. Ishii, K. Suzuki,M. Gursel, D.M.
Klinman, Signal transduction pathways mediated by the interaction
of CpG DNA with toll-like receptor 9, Semin. Immunol. 16, 17-22,
2004
- K.J.Ishii, K.Kawakami, İ. Gürsel, B.H.Joshi, D.M. Klinman,
R.K. Puri.Anti-tumor therapy with bacterial DNA and toxin:
complete regression of established tumor induced by liposomal CpG
ODN plus IL-13 cytotoxin, Clin. Cancer Res. 9(17) , 6516-6522,
2003
- D.M. Klinman, R.A. Zeuner, H. Yamada, M. Gursel, D. Currie,
İ. Gürsel, Regulation of CpG-induced immune activation by
suppressive oligodeoxy-nucleotides, Ann. N.Y. Acad. Sci. 1002,
112-123, 2003
- İ. Gürsel, M. Gursel, H. Yamada, F. Takeshita, K.J. Ishii,
D.M. Klinman, Repetitive elements present in mammalian telomeres
suppress CpG DNA induced immune activation, J. Immunol.
171:1393-1400, 2003 ( this study was picked as the cover story:
http://www.jimmunol.org/content/vol171/issue3/cover.shtml ).
- A. Yagmurlu, M. Barlas, İ. Gürsel. I.H. Gokcora, Reduction of
injury induced peritoneal adhesions by continuous release of
streptokinase from a drug delivery system, Eur.Surg.Res.
35(1):46-49, 2003
- H. Yamada, İ. Gürsel, F. Takeshita, J. Conover, K. J. Ishii,
M. Gursel, S. Takeshita, and D.M. Klinman, Effect of Suppressive
DNA on CpG-Induced Immune Activation, J. Immunol. 169: 5590-5594,
2002.
- D.M. Klinman, K.J. Ishii,İ. Gürsel, Immunoprotective activity
of CpG oligonucleotide, In. Microbial DNA and Host Immunity, ed.
Raz E, Humana Press, 255-263, 2002.
- R.A. Zeuner, K.J. Ishii, M. Lizak, İ. Gürsel, H. Yamada, D.M.
Klinman, D. Verthelyi, Prevention of inflammatory arthritis by
suppressive oligodeoxynucleotides, Arthritis Rheum. 46(8)
2219-2224, 2002.
- D.M. Klinman , F. Takeshita , İ. Gürsel , C. Leifer, K.J.
Ishii, D. Verthelyi, M. Gursel , CpG DNA: recognition by and
activation of monocytes, Microbes Infection,4(9) 897-901, 2002.
- K.J. Ishii, F. Takeshita, İ. Gürsel, M. Gursel, J. Conover,
A. Nussenzweig, D.M. Klinman, Potential role of PI3 kinases,
rather than DNA-PK, in CpG DNA induced immune activation, J. Exp.
Med. 196(2):269-74, 2002.
- M. Gursel, D. Verthelyi, İ. Gürsel , K.J. Ishii, D.M. Klinman,
Differential and competitive activation of human immune cells by
distinct classes of CpG oligodeoxynucleotide, J. Leuko. Biol,
71(5):813-820, 2002.
- H.A. Anderson, R. Englert, İ. Gürsel, E. Shacter, Oxidative
stress inhibits the phagocytosis of apoptotic cells that have
externalized phosphatidylserine Cell Death Differ. 9(6):616-625,
2002.
- İ. Gürsel , M.F. Yagmurlu, F. Korkusuz, V. Hasirci, In vitro
antibiotic release from
poly(hydroxybutyrate-co-3-hydroxyvalerate) rods, J.
Microencapsulation 19:(2)153-164, 2002.
- F. Takeshita, C. Leifer, İ. Gürsel, M. Gursel, K.J. Ishii,
D.M. Klinman, Role of Toll-like receptor-9 in CpG DNA induced
activation of human cells. J. Immunol. 167(7):3555-3558, 2001.
- İ. Gürsel , M. Gursel, K.J. Ishii, D.M. Klinman, Sterically
stabilized cationic liposomes improve the uptake and
immunostimulatory activity of CpG oligonucleotides, J.
Immunol.167(6):3324-3328, 2001.
- F. Korkusuz, P. Korkusuz, F. Eksioglu, İ. Gürsel, V. Hasirci,
In vivo response to biodegradable antibiotic release systems, J.
Biomed. Mater. Res. 55:217-228, 2001.
- İ. Gürsel , F. Korkusuz, F. Turesin, N.G Alaeddinoglu, V.
Hasirci, In vivo application of biodegradable controlled
antibiotic release systems for the treatment of implant-related
osteomyelitis, Biomaterials22:(1) 73-80, 2001.
- D.M. Klinman, S. Kampstrup, D. Verthelyi, İ. Gürsel , K.J.
Ishii, F. Takeshita, M. Gursel, Activation of the innate immune
system by CpG: Therapeutic applications and safety issues,
Springer Semin. Immunopharmacol. 2(1-2): 173-183, 2000.
- D.M. Klinman, K.J. Ishii, M. Gursel, İ. Gürsel , S. Takeshita
and F. Takeshita, Immunotherapeutic applications of CpG
containing oligodeoxynucleotides, Drug News and
Perspectives13(5),289-296, 2000.
- F. Türesin, Z. Gümüsyazici, F.N. Kök, İ. Gürsel , N.G.
Alaeddinoglu V. Hasirci, Biosynthesis of polyhydroxybutyrate and
its co-polymers and their use in controlled drug release, Turkish
J. Med. Sci30:535-541 2000.
- D. Sendil, İ. Gürsel , V. Hasirci, Preparation of PHBV foams
and investigation of their potential for drug release, Tr. J.
Med. Sci. 30: 9-14, 2000.
- F. Eksioglu, İ. Gürsel, F. Korkusuz, V. Hasirci, Novel
antibiotic carrying biodegradable implant for the treatment of
bone infections, J. Bone Joint Surg. [BR] 81-B: Supp II p.179,
1999.
- M.F. Yagmurlu, F. Korkusuz, İ. Gürsel, P. Korkusuz, U. Ors,
V. Hasirci, Sulbactam-cefoperazone
polyhydroxybutyrate-co-hydroxyvalerate (PHBV) local antibiotic
delivery system: In vivo effectivity and biocompatibility in the
treatment of implant related experimental osteomyelitis, J.
Biomed. Mater. Res.46, 494-503, 1999.
- S. Bayari, F. Severcan, İ. Gürsel , V. Hasirci, N.G.
Alaeddinoglu, The FTIR studies of PHB and PHBV, In. New
Biomedical Materials, eds. P. I. Haris and D. Chapman, IOS Press,
58-64, 1998.
- D. Sendil, İ. Gürsel , D.L. Wise, and V. Hasirci, Antibiotic
Release from biodegradable PHBV microparticles, J. Contr.
Rel.59,207-217, 1999.
- İ. Gürsel , C. Balçık, Y. Arica, O. Akkuş, N. Akkaş, V.
Hasirci, Synthesis and mechanical properties of interpenetrating
networks of polyhydroxybutyrate-co-hydroxyvalerate and
polyhydroxyethyl methacrylate, Biomaterials,19(13):1137-1143,
1998.
- İ. Gürsel , N.G. Alaeddinoglu, Bacterial
polyhydroxyalkanoates: Biosynthesis, screening and
characterization, In. Biopharmaceutical and Biomedical Science
and Technology, eds. A.A. Hıncal, H. S. Kaş, Plenum Press, NY,
USA, 81-88, 1998.
- İ. Gürsel , D. Sendil, D. L. Wise, V. Hasirci, Antibiotic
release from biodegradable PHBV microparticles, In.
Biopharmaceutical and Biomedical Science and Technology, eds. A.A.
Hıncal, H. S. Kaş, Plenum Press, NY, USA, 89-96, 1998.
- V. Hasirci, İ. Gürsel , F. Turesin, G. Yigitel, F. Korkusuz,
N.G. Alaeddinoglu, In. Biopharmaceutical and Biomedical Science
and Technology, Eds. A.A. Hıncal ve H. S. Kas, Plenum Press, NY,
USA, 183-187, 1998
- İ. Gürsel , Y. Arica, V. Hasirci, Immobilization of glucose
oxidase and urease, in hydrogel matrices, Turkish J. Chem.
21(4):387-393, 1997.
- G. Gregoriadis. İ. Gürsel , M. Gursel, B. Mc. Cormack,
Liposomes as immunological adjuvants and vaccine carriers, J.
Contr. Rel. 41:49-56, 1996.
- G. nGregoriadis İ. Gürsel , and S.G.Antimisiaris, Microbe
entrapment in giant liposomes, In: Non-Medical Applications of
Liposomes:"From Gene Delivery and Diagnostics to Ecology" , eds.
D. L. Lasic and Y. Barenholz, CRC Press, Boca Raton, Vol. IV,
263-269, 1996.
- İ. Gürsel , C. Balcik, Y. Arica, O. Akkus, V. Hasirci, and N.
Akkas, Interpenetrating networks of
polyhydroxybutyrate-co-hydroxyvalerate, and polyhydroxyethyl
methacrylate : Mechanical properties, Engineering Systems Design
and Analysis, 5:107-111, 1996.
- İ. Gürsel , Use of microbial polyhydroxyalkanoates in the
construction of biomedical drug release systems, Ph. D. Thesis (M.E.T.U),
February 1995.
- İ. Gürsel , and V. Hasirci, Microcapsules of PHB and PHBV:
morphology and release characteristics, J. Microencapsulation,
12(2):185-193, 1995.
- İ. Gürsel , P.Jayasekera, S.G. Antimisiaris, and
G.Gregoriadis, Giant Liposomes as potential vehicles for live or
attenuated microbial vaccines, In: Liposomes in Biomedical
Applications, ed. P.Shek, Harwood Academic Publishers, Chur,
35-50, 1995.
- İ. Gürsel , and V. Hasirci, Matrix entrapment of glucose
oxidase by gamma-irradiation, Biomaterials, 13(3):150-155, 1992.
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